Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

In further support of a reduction in mitochondrial functions, proteins of complexes I and II were significantly less abundant in DA1-3b/M2 cells than in DA1-3b cells, complexes IV and V appeared less expressed in DA1-3b/M2 cells but failed to reach statistical significance, complex III remained similar in both cell lines ( Fig. 3F ).

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