a strong trendP = 0.0508
RASS results ( 13 ) were consistent with those of ∼5 years DIRECT-Prevent 1 ( 14 ) where there was a strong trend ( P = 0.0508) for a reduction in the primary end point, time to two-steps or more DR progression, in type 1 diabetic patients with no DR at baseline who were randomized to candesartan.