Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.

Randomized controlled preclinical and clinical studies with detergent-based microbicides such as nonoxynol-9 showed a trend towards evidence of harm, with increased incidence of not only HIV-1 infection, but also HSV-2 and HPV seen in the experimental arms [33] , [34] , [35] , [36] , [37] .

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