In the ADVANCE trial, a prospective, randomized, controlled trial that evaluated the progression of vascular and cardiac valve calcification in 360 prevalent adult hemodialysis patients with secondary hyperparathyroidism after receiving treatment with cinacalcet plus low-dose vitamin D sterols versus flexible doses of vitamin D sterols alone, a trend towards less progression of coronary artery Agatston calcium score was observed in the cinacalcet-treated group after 52 weeks versus the flexible vitamin D sterol group but did not reach statistical significance.
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Vascular and valvular calcification in chronic peritoneal dialysis patients.
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