Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age.

A positive trend between ALP activity and Oil Red O staining (R 2 = 0.405, p = 0.055) almost reached significance ( Fig. 5F ), giving a clear indication that MSC populations with strong adipogenesis are not weak in osteogenesis and vice versa as this may be expected from the in vivo observation that during lifetime the bone marrow is replaced by fat marrow.

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A weak trend to more lipid deposition with younger age was not reflected by gene expression analysis of the adipogenic marker Peroxisome proliferator-activated receptor gamma (PPARG) in cells from the five youngest and five oldest donors of the study ( Fig. 3G ).

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A positive trend between ALP activity and Oil Red O staining (R 2 = 0.405, p = 0.055) almost reached significance ( Fig. 5F ), giving a clear indication that MSC populations with strong adipogenesis are not weak in osteogenesis and vice versa as this may be expected from the in vivo observation that during lifetime the bone marrow is replaced by fat marrow.

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MSC with high osteogenic capacity underwent better chondrogenesis and showed a trend to better adipogenesis.

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