Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline.

At 300 mg/kg BW MCT dose, right ventricular pressures showed a modest increase versus saline treatment but did not reach statistical significance (WT/saline: 6.6±0.8, n = 4; COX-2KD/saline: 6.7±0.7, n = 6; WT/MCT: 9.8±0.9, n = 5; COX-2KD/MCT: 8.2±2.7 mmHg, n = 3).

also in 111,027 other papers