It seems that the suppression of PPARα functions may be significant under pathological, rather than physiological, conditions with increased bile acid concentrations.
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Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
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SREBP-1c , which regulates transcription of these lipogenic genes, decreased slightly, but did not reach statistical significance ( Fig. 4a ).