Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

For E746-A750 deletion, the AUC difference did not reach statistical significance, although the logistic regression model based on E746-A750 Q score and total EGFR expression IHC intensity had a higher AUC than E746-A750 intensity only.

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showed that positive IHC staining of the two mutation-specific antibodies produced a nonsignificant trend toward a favorable clinical outcome, including overall survival and PFS [13] .

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