weakly significantP=0.04
Despite the strong correlation between maps at megabase scales, there is mounting evidence that PRDM9 ’s influence on crossing-over may not be limited to fine scales 4 , 11 : we observe a weakly significant association of rs6889665 with the total number of crossovers genome-wide in pedigrees (P=0.04), corresponding to an average 1.3 crossovers more per meiosis per derived allele, exceeding the strongest previously known association 23 at RNF212 .