Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

Although no significant difference was found either by Mann–Whitney rank sum or students t test between treated and untreated G1KD tumors, the TDG treated tumors did show a clear trend with reduced weight suggesting a residual effect of TDG on the remaining galectin-1 produced by the G1KD tumors.

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The inhibitory effects of TDG on the pro-angiogenic function of galectin-1 were shown to be highly significant, both in vitro and in vivo, reducing binding to laminin and the tube-forming activity of ECs, as well as EC proliferation (Fig. 6 ).

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