Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice.

While α5IA strongly reduced thigmotaxy in Ts65Dn mice ( F 1,28 = 15.74; p < 0.001) these mice still displayed increased thigmotaxy after α5IA treatment (comparison with euploids: F 1,28 = 4.81, p < 0.05). In addition, in euploid mice, the thigmotaxy-reducing effect of α5IA, although observed (see Figure 3 ), did not reach statistical significance ( F 1,28 = 2.57, p = ns).

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