Declining β-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth.

ANOVA across groups showed a significant trend for declining insulin sensitivity ( Fig. 2 A ) and first-phase insulin ( Fig. 2 B ) as 2-h glucose increased, and both differed significantly at the extremes of the glucose categories (<120 mg/dL vs. ≥200 mg/dL).

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