showed a trendP = 0.190
When soluble protein levels were analyzed as continuous variables using the Cox proportional hazards model, baseline VEGF-C was the only soluble protein significantly associated with TTP by univariate analysis (HR = 0.413; P = 0.0165) and showed a trend towards an association with OS (HR = 0.683; P = 0.190; Table 4 ). sVEGFR-2 ratio to baseline at cycle 1 day 28 was the only soluble protein significantly associated with OS (HR = 0.049; P = 0.0253).