Longitudinal analysis of arterial blood pressure and heart rate response to acute behavioral stress in rats with type 1 diabetes mellitus and in age-matched controls.

control rats during months 4–9 Like Cadre 1, the peak increase in mBP for C 1 for Cadre 2 rats averaged over 4–9 months diabetes duration was similar for the matched control (+ 3.5 ± 1.3 mm Hg) and diabetic rats (+ 2.6 ± 0.8 mm Hg; NS) and neither group showed a trend to change the magnitude of the response across time.

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In contrast to the conditional responses for both groups shown in Figure 2 , the diabetic rats had lost the initial C 1 mBP pressor response at this later phase in the development of diabetic pathophysiology (upper left insert, Figure 5 ), though, given the small “ n ” for the BB animals, this between group difference fell short of significance (CS+: F 1,18 = 3.97; CS−: F 1,18 = 1.49).

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