Demographic variation in incidence of adult glioma by subtype, United States, 1992-2007.

Calendar period We observed trends of increasing GBM incidence rate and decreasing non-GBM incidence rate with more recent period, with an overall trend for GBM and non-GBM combined of slightly decreasing rate.

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For GBM, we observed a significant trend of increasing RR with more recent period; however, the magnitude of the increase in incidence rate was not large (6% increase between 1992-1995 and 2004-2007).

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Overall, for GBM and non-GBM combined, we observed a slight trend of decreasing incidence rate with more recent period (3% decrease between 1992-1995 and 2004-2007).

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The difference in race/ethnic variation between GBM and non-GBM was highly significant among both males and females (p-value for heterogeneity < 0.0001 in each sex).

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