Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia.

3 ). Social novelty Repeated measures ANOVAs did not reveal any significant effects of genotype in the preference for social novelty test, although the genotype x side interaction approached significance in the Erbb3 group [ F (1,20) = 4.24, p = 0.0527].

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Interestingly, Grin1 D481N mice had persistent deficits in sociability in the three-chambered choice task, but highly significant preference for stranger 2, providing evidence that reduced NMDAR function does not disrupt social novelty preference [ 30 ].

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