Choline transporter gene variation is associated with attention-deficit hyperactivity disorder.

In our within-family association study, although we observed no association between the overall ADHD diagnosis or any diagnostic subtype with the 3’SNP on its own, we detected a highly significant association of a two locus haplotype comprised of the CHT Val89 allele and the 3’SNP minor allele.

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In the Vanderbilt/Chicago ADHD panel, the allele frequency for the CHT 3’SNP major allele was slightly elevated (79%), though this change did not reach statistical significance.

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