White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents.

When gender was added as a covariate, a small cluster was localised to the left frontal lobe but subsequently did not reach statistical significance when correction for type I error was applied. 22q11DS vs. controls FA (controlled for IQ) Significant widespread FA deficits were found in the 22q11DS group relative to healthy controls that extended from the brainstem to more superior brain sections.

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