Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.

PLoS One · 2011 · PMC3166157 · PMID 21912619

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did not reach statistical significanceno p-value reported

The percent of CS protein peptide specific CD3 + CD8 + perforin + cells also tended to be higher in animals given the Ad-EAT2+Ad-CSP vaccination cocktails however this did not reach statistical significance ( Figure 4C ).

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