Meta-analysis of the immunogenicity and tolerability of pandemic influenza A 2009 (H1N1) vaccines.

The PIE indexes were 0.87 (one dose only) and 0.86 (two doses), suggesting large diversity in the networks, and the co-occurrence was formally statistically significant or close to significance, suggesting that there was strong preference for some comparisons (C-score p-values = 0.03 and 0.06 for single dose and two doses networks).

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Overall, it was not possible to note a clear trend, with studies at higher risk of bias showing sometimes higher sometimes lower summary estimates than trials at lower risk of bias (and most confidence intervals overlapping).

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