However, these differences did not reach statistical significance (Supplementary Figures 9a and b). siCASP2 induces specific RNAi-mediated caspase-2 mRNA cleavage in vivo To verify that RNAi activity was induced by siCASP2 in rat retinas after intravitreal administration, we used the RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) method to detect the presence of caspase-2 mRNA-specific cleavage product in rat retina.
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