Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization.

PLoS One · 2011 · PMC3169605 · PMID 21931705

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showed a trendno p-value reported

However, all 6 comparisons showed a trend towards stronger response with PDE2-CAMYEL, suggesting that membrane-proximal cAMP levels may be slightly higher than in bulk cytosol.

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highly significantno p-value reported

However, the cAMP BRET response at the plasma membrane was higher than in the cytosol in 23 out of 24 comparisons, which is highly significant.

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