Genetic architecture of prostate cancer in the Ashkenazi Jewish population.

After removing 26 individuals without age information and adjusting for age as a covariate, nine SNPs were nominally significant ( P <0.05), of which three are significant at a false discovery rate of 5% ( Table 3 ).

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However, it has been suggested that there may be significant local differences in allele frequencies and haplotype structure between the Ashkenazi population and other European populations, including at loci associated with common cancer ( Gold et al , 2008 ; Olshen et al , 2008 ; Price et al , 2008 ; Tian et al , 2008 ).

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