nominally significantP ≤ 0.05
Polymorphisms in IL-8, HIF1A, NR1l2, and VEGFA showed nominally significant association ( P ≤ 0.05) with PFS when compared with the wild-type genotypes.
Polymorphisms in IL-8, HIF1A, NR1l2, and VEGFA showed nominally significant association ( P ≤ 0.05) with PFS when compared with the wild-type genotypes.
Conclusion: role of pazopanib in RCC therapy In the Phase III randomized double-blind placebo-controlled trial, pazopanib treatment produced a highly significant PFS improvement for either treatment-naïve or cytokine pretreated patients.
The survival data suggest a favorable trend associated with pazopanib treatment, in spite of significant crossover by subjects in the placebo arm.