Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

showed a trend toward being reduced when MyD88-deficient DCs were used and toward being increased when IL-12–deficient DCs were used ( Fig. 4 E ). iNKT cells freshly isolated from WT mice by tetramer sorting also showed a strong dependence of the iNKT cell IFN-γ production on MyD88 and IL-12, whereas little or no IL-4 was generated ( Fig.

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