Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories.

PLoS Comput Biol · 2011 · PMC3178621 · PMID 21966264

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a negative trendno p-value reported

To our surprise, we found that almost half of the 21 pairs tested showed a negative trend, and that 5 out of 12 significant sign-epistatic interactions were negative.

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