Cyclin D1 was significantly increased in both male and female Col1(2.3) + /PTX + mice, cyclin D2 showed a trend toward being increased in females, and no change was seen in cyclin E1 ( Fig. 5 E ).
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Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
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