Combinational treatment with scFv62-TRAIL and etoposide or 5-fluorouracil significantly increased the apoptosis induction by scFv62-TRAIL, whereas the increase in apoptosis produced by combination with actinomycin D, doxorubicin or roscovitine did not reach statistical significance.
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Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody.
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