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Current research in child and adolescent bipolar disorder.

Dialogues Clin Neurosci · 2008 · PMC3181873 · PMID 18689291

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90 Furthermore, although the decrease in manic symptoms in the lithium group did not reach statistical significance in comparison with the placebo group, there was a decrease of greater magnitude in manic symptoms in the lithium group when compared with the placebo. 90 Notably, this trend for lithium to be efficacious may become more definitively substantiated in subsequent studies in which higher lithium doses or a larger sample size is employed.

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