A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

PLoS One · 2011 · PMC3182219 · PMID 21980439

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantP <0.05actually significant

We found that four SNPs showed nominally significant associations at P <0.05 for rs26232 ( C5orf30 ), rs2073838 ( SLC22A4 ), rs11676922 ( AFF3 ), and rs7528684 ( FCRL3 ).

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highly significantno p-value reported

For the HLA-DRB1 alleles, HLA-DRB1*04:05 allele showed highly significant evidence of association with the risk of RA.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.