Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain.

Spinal application of Tat-NR2B9c minimally reduced the response to brush in both surgical groups to a similar level, but this effect did not reach statistical significance ( Figure 5a,b ; 12.5 ng, n = 6 in each group, sham: APs = 298 ± 88, P > 0.05; SNL: APs = 270 ± 137; P > 0.05).

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