MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.

MYCN -only amplified cell lines were also more sensitive to Nutlin-3 mediated growth inhibition compared to MYCN and MDM2 co-amplified neuroblastoma cell lines ( Figure 5Bii ) (p<0.01) and although this difference did not reach statistical significance, the same trend was observed for MI-63 ( Figure 5Dii ).

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