Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.

Interestingly, hGSTP1 + mGstp1/2 −/− mice exhibited an intermediate level of sensitivity to acetaminophen relative to the wildtype and mGstp1/2 −/− mice – elevations of AST and ALT at 24 hours in hGSTP1+mGstp1/2−/− mice were significantly greater than those in mGstp1/2−/− mice but showed a trend to be lower than those seen in wildtype mice ( Figure 6A–B ).

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