Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.

PLoS Genet · 2011 · PMC3192827 · PMID 22022281

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failed to reach statistical significanceno p-value reported

Further, gene expression analysis by qPCR demonstrated a significant induction of BiP and CHOP mRNAs in denervated muscle, while ATF4 mRNA levels exhibited a similar trend that failed to reach statistical significance ( Figure 4B ).

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