In a phase II randomized, placebo-controlled clinical trial of green tea extract (500, 750, or 1,000 mg/m 2 ) in high risk oral premalignant lesions (OPL), the OPL clinical response rate was higher in all green tea extract (GTE) arms versus placebo but did not reach statistical significance [ 82 ].
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The chemopreventive properties and therapeutic modulation of green tea polyphenols in oral squamous cell carcinoma.
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