Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion.

Initial analysis of the effect of inhibition of type-I PKA anchoring – by determining the proportion of invaded cells that were transfected (or ‘IX/I’) - showed a trend toward decreased invasion, although this was not statistically different from the scrambled control ( Figure 8A , gray bars ; P = 0.097); however, upon normalizing the data for transfection efficiency ( i.e. the number of invading, transfected cells over the total number of transfected cells, or ‘IX/X’), there was indeed a statistically significant (P<0.05) inhibition of invasion caused by disruption of RI anchoring ( Figure 8B , gray bars ).

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