Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.

BMAL1 binding showed a similar pattern with maximal levels reached at ZT6 and a minimum at ZT18- or -0 for Cry1 (F 3,56 = 4.3, p<0.01) and Dbp (F 3,56 = 2.9, p<0.05), whereas, although similar, the time-of-day changes in Per1 and Per2 binding did not reach statistical significance (F 3,60 = 1.7, p = 0.2, n.s. for Per1 ; F 3,67 = 2.2, p = 0.09, n.s. for Per2 ).

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