However, when subsets of CD8 T cells were enumerated, there was a dramatic and highly significant loss of naive (CD45RA + CCR7 + ) cells (∼10% in patients compared with ∼45% in normal controls), together with a smaller but still significant decrease in memory (CD45RA − CCR7 −/+ ) CD8 T cells.
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DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
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The sentences
Slightly lower expression of Bcl2 and Bim was observed in mutant OT-I cells on day 7 of the primary influenza response, but this did not reach statistical significance in one of two experiments (not depicted).