Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

PLoS One · 2011 · PMC3202540 · PMID 22046307

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approaches statistical significanceno p-value reported

Despite the small sample size due to the unavailability of tissue, the 1.7-fold decrease in AβPP/AβPPα in neocortex approaches statistical significance.

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a strong trendno p-value reported

There is a strong trend toward increased soluble Aβ 1–40 in lysates of FXS brain samples ( Figure 6D ) while AβPP/AβPPα levels are reciprocally decreased ( Figure 6C ) in both the neocortex and hippocampus.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.