A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.

Multivariate logistic regression analysis showed that after adjusting for confounding factors, compared with CC genotypes, CA had a significantly increased risk of lung cancer (adjusted odds ratios [OR] = 1.31; 95% CI = 1.01–1.68; P = 0.0436), the AA homozygote had a non-significantly increased risk of lung cancer (adjusted OR = 1.90; 95%CI = 0.80–4.53; P = 0.1438) because of its rare frequency, but there was a significant trend for an allele dose effect on risk of lung cancer ( P trend = 0.0158).

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