Discovering biological connections between experimental conditions based on common patterns of differential gene expression.

For example, GSE6710 [ 35 ], a dataset that compared gene expression in psoriatic lesions with normal skin, was assigned a significant q value by openSESAME ( q = 0.0109 by Fisher's exact test), but received only a moderately significant FDR-corrected p value (0.0775) from MARQ. openSESAME also assigned high significance (Fisher q = 0.000452) to GSE2280 [ 36 ], which was not assigned a significant p value by MARQ.

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