Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes.

Although the effects did not reach statistical significance, IDFP decreased, while AM251 pretreatment partially restored, the glucose-lowering efficacy of insulin ( Fig. 3B ). 1.3 IDFP Alters Hepatic Gene Expression 1.3.1 Cluster Analysis To identify the pathways activated by IDFP administration, specifically those dependent on CB1 activation, microarray analysis was performed on hepatic mRNA from DMSO, IDFP and AM251/IDFP-treated animals.

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