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Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus.

PLoS One · 2011 · PMC3208633 · PMID 22076148

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There is a tendency for imipramine to decrease BrdU labeling in p21-/- mice, although this effect did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.