Weak association of anti-sperm antibodies and strong association of familial cryptorchidism/infertility with HLA-DRB1 polymorphisms in prepubertal Ukrainian boys.

Reprod Biol Endocrinol · 2011 · PMC3214188 · PMID 21955839

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weakly significantno p-value reported

However, weakly significant differences in DRB1*04 ( p corrected = 0.0475) and DQB1*06 ( p corrected = 0.0385) were seen between cryptorchid patients with and without AsA, but none of these two patient groups differed significantly in HLA class II frequencies from controls except for AsA-negatives and HLA-DQB1*06 ( p corrected = 0.0247).

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highly significantno p-value reported

On the other hand, comparison of cryptorchid boys with familial cryptorchidism and/or infertility to control boys revealed highly significant ( p corrected = 0.0006) difference in HLA-DRB*11 frequency, whereas boys with sporadic cryptorchidism did not differ from control.

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