The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes.

In pregnancies where the mother had blood group O, the frequency of newborns with severe NAIT was 9%, where the mother did not carry any O0 2 allele, compared to 27% where the mother carried one or two O02 alleles; however, this did not reach statistical significance (relative risk 0.33 NS P = 0.13).

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Although the differences in the O02- positive and O02 -negative subgroups of blood group O do not reach statistical significance, an interesting trend is observed.

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