Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts.

Coincidentally, IFN-β, IL-6 and MMP3 expression of FLSs, which were stimulated with pristane-primed T cells for 24 hours, showed significantly high levels compared with those stimulated with control T cells, whereas MMP13 expression showed a trend toward upregulation (Figure 3C ).

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