Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1.

This was clearly reflected in the Ki-67 immunostaining of MCF-7 cells, with HRGβ1 increasing nuclear Ki-67 positivity scores, expressed as mean ± SD, from 55 ± 4.5% to 89 ± 1.8% in MCF-7 cells ( P < 0.01, n = 3); however, in T47D cells, although an increase from 41 ± 3.6% to 49 ± 5.8% was observed in response to HRGβ1 in the presence of fulvestrant, it did not reach statistical significance (Table 1 and Additional file 1 , Supplementary Figure S1).

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