Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

No differences in survival were observed for patients treated with chemotherapy when stratified by Treg infiltration ( P = 0.565) CXCL12 expression does not differ between the different intrinsic subtypes, and is associated with longer survival Although a smaller proportion of basal-like (16/27, 59%) and HER2 tumours (25/47, 53%) was positive for CXCL12 expression compared with luminal tumours (102/138, 74%), this did not reach statistical significance ( P = 0.050) (Table 2 ).

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While CXCL12 expression is associated with a favourable prognosis in an analysis of all breast cancers, there may be significant heterogeneity in the impact of CXCL12 on tumour behaviour between subtypes.

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