Barely Significant
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Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart.

PLoS One · 2011 · PMC3219639 · PMID 22125598

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a clear trendno p-value reported
Interestingly, there was a clear trend towards an increased expression of UCP3 in DCM hearts of patients who had not received metoprolol as compared to non-failing myocardium.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.