Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients.

Specifically, we could demonstrate an inverse association with renal function as displayed by highly significant correlations with the glomerular filtration rate of cystatin C (r = -0.649, P < 0.001), cystatin C (r = 0.638, P < 0.001), creatinine (r = 0.352, P < 0.0001) and urea (r = 0.400, P < 0.001) serum concentrations (Table 3 ), indicating renal clearance of suPAR.

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However, differences among non-sepsis patients (SIRS vs non-SIRS) did not reach statistical significance.

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